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The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor

Meiers, S. ; Kemény, M. ; Weyand, U. ; Gastpar, R. ; Angerer, E. von ; Marko, D.



Abstract

The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), were found to inhibit the growth of human tumor cells in vitro in the micromolar range, whereas malvidin (mv), a typical anthocyanidin in grapes, was less active. The aglycons preferentially inhibited the growth of the human vulva carcinoma cell line A431, overexpressing the epidermal growth-factor ...

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