Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines.

Bouchal, Jan, Baumforth, Karl R N, Sváchová, Michaela, Murray, Paul G, Angerer, Erwin von und Kolár, Zdenek (2005) Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. The Journal of pharmacy and pharmacology 57 (1), S. 83-92.

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Zusammenfassung

Bicalutamide is a non-steroidal anti-androgen commonly used in the treatment of prostate carcinoma. We analysed the transcriptional response to bicalutamide treatment with the aim of explaining the inhibition of telomerase in the androgen-sensitive cell line LNCaP and the effects of bicalutamide on the androgen-insensitive cell line DU145. Cells treated with 80 muM bicalutamide in ...

Bibliographische Daten exportieren

Dokumentenart:

Artikel

Datum:

2005

Institutionen:

Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer)

Identifikationsnummer:

Wert	Typ
15638997	PubMed-ID
10.1211/0022357055164	DOI

Klassifikation:

Notation	Art
Androgen Antagonists/pharmacology	MESH
Androgens/pharmacology	MESH
Anilides/pharmacology	MESH
Blotting, Western	MESH
Cell Line, Tumor	MESH
Cell Survival/drug effects	MESH
Gene Expression Regulation/drug effects	MESH
Genes, p53/drug effects	MESH
Humans	MESH
Male	MESH
Nitriles	MESH
Oligonucleotide Array Sequence Analysis	MESH
Prostatic Neoplasms/genetics	MESH
RNA/biosynthesis	MESH
Reverse Transcriptase Polymerase Chain Reaction	MESH
Telomerase/metabolism	MESH
Tetrazolium Salts	MESH
Thiazoles	MESH
Tosyl Compounds	MESH