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2,5-Diphenylfuran-based pure antiestrogens with selectivity for the estrogen receptor alpha

Zimmermann, Jochen ; Liebl, Renate ; Angerer, Erwin von



Abstract

The estrogen receptor alpha (ERalpha) is understood to play an important role in the progression of breast cancer. Therefore, pure antiestrogens with a preference for this receptor form are of interest as new agents for the treatment of this malignancy. Several chemical structures with selective binding affinity for ERalpha have been identified and might be useful for the synthesis of ...

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