Zimmermann, Jochen and Angerer, Erwin von (2007) Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β. The Journal of Steroid Biochemistry and Molecular Biology 104 (3-5), pp. 259-268.
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Abstract
The estrogen receptor (ER) exists in two isoforms ERα and ERβ with a different distribution in the body and different functions which are not clearly identified yet. Thus, it is desirable to have both agonists and antagonists with selectivity for one or the other ER isoform available. In a previous study we showed that 2,5-diphenylfurans can be converted into pure antiestrogens with preference ...
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| Item type: | Article | ||||||||||||||||||||||||||
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| Date: | 2007 | ||||||||||||||||||||||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||||||||||||||||||||||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie | ||||||||||||||||||||||||||
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| Keywords: | Non-steroidal estrogen; Antiestrogen; Hormone-dependent breast cancer; Diphenylfuran; Estrogen receptor β | ||||||||||||||||||||||||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||||||
| Created at the University of Regensburg: | Yes | ||||||||||||||||||||||||||
| Item ID: | 4786 |
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