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Semiautomated quantification of the fibrous tissue response to complex three‐dimensional filamentous scaffolds using digital image analysis

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Barsch, Friedrich ; Mamilos, Andreas ; Babel, Maximilian ; Wagner, Willi L. ; Winther, Hinrich B. ; Schmitt, Volker H. ; Hierlemann, Helmut ; Teufel, Andreas ; Brochhausen, Christoph
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 24 Aug 2021 09:27

This publication is part of the DEAL contract with Wiley.


Fibrosis represents a relevant response to the implantation of biomaterials, which occurs not only at the tissue–material interface (fibrotic encapsulation) but also within the void fraction of complex three-dimensional (3D) biomaterial constructions (fibrotic ingrowth). Usual evaluation of the biocompatibility mostly depicts fibrosis at the interface of the biomaterial using semiquantitative ...


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