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Development of Randomized Trials in Adults with Medulloblastoma—The Example of EORTC 1634-BTG/NOA-23

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Hau, Peter ; Frappaz, Didier ; Hovey, Elizabeth ; McCabe, Martin G. ; Pajtler, Kristian W. ; Wiestler, Benedikt ; Seidel, Clemens ; Combs, Stephanie E. ; Dirven, Linda ; Klein, Martin ; Anazodo, Antoinette ; Hattingen, Elke ; Hofer, Silvia ; Pfister, Stefan M. ; Zimmer, Claus ; Kortmann, Rolf-Dieter ; Sunyach, Marie-Pierre ; Tanguy, Ronan ; Effeney, Rachel ; von Deimling, Andreas ; Sahm, Felix ; Rutkowski, Stefan ; Berghoff, Anna S. ; Franceschi, Enrico ; Pineda, Estela ; Beier, Dagmar ; Peeters, Ellen ; Gorlia, Thierry ; Vanlancker, Maureen ; Bromberg, Jacoline E. C. ; Gautier, Julien ; Ziegler, David S. ; Preusser, Matthias ; Wick, Wolfgang ; Weller, Michael
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Aug 2021 15:10


Simple Summary Medulloblastoma is rare after puberty. Among several molecular subgroups that have been described, the sonic hedgehog (SHH) subgroup is highly overrepresented in the post-pubertal population and can be targeted with smoothened (SMO) inhibitors. However, no practice-changing prospective clinical trials have been published in adults to date. Tumors often recur, and treatment ...


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