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Increased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyes

Vahabikashi, Amir ; Gelman, Ariel ; Dong, Biqin ; Gong, Lihua ; Cha, Elliott D. K. ; Schimmel, Margit ; Tamm, Ernst R. ; Perkumas, Kristin ; Stamer, W. Daniel ; Sun, Cheng ; Zhang, Hao F. ; Gong, Haiyan ; Johnson, Mark


The cause of the elevated outflow resistance and consequent ocular hypertension characteristic of glaucoma is unknown. To investigate possible causes for this flow resistance, we used atomic force microscopy (AFM) with 10-mu m spherical tips to probe the stiffness of the inner wall of Schlemm's canal as a function of distance from the tissue surface in normal and glaucomatous postmortem human ...


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