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Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus

Kaiser, Marco ; Wurm, Jan Philip ; Märtens, Birgit ; Bläsi, Udo ; Pogoryelov, Denys ; Wöhnert, Jens



Abstract

During translation initiation, the heterotrimeric archaeal translation initiation factor 2 (aIF2) recruits the initiator tRNA(i) to the small ribosomal subunit. In the stationary growth phase and/or during nutrient stress, Sulfolobus solfataricus aIF2 has a second function: It protects leaderless mRNAs against degradation by binding to their 5 '-ends. The S. solfataricus protein Sso2509 is a ...

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