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Molecular Composition of Genomic TMPRSS2-ERG Rearrangements in Prostate Cancer

Krumbholz, Manuela ; Agaimy, Abbas ; Stoehr, Robert ; Burger, Maximilian ; Wach, Sven ; Taubert, Helge ; Wullich, Bernd ; Hartmann, Arndt ; Metzler, Markus


There is increasing interest in the use of cell-free circulating tumor DNA (ctDNA) as a serum marker for therapy assessment in prostate cancer patients. Prostate cancer is characterized by relatively low numbers of mutations, and, in contrast to many other common epithelial cancers, commercially available single nucleotide mutation assays for quantification of ctDNA are insufficient for therapy ...


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