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The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease

Srinagesh, Hrishikesh K. ; Özbek, Umut ; Kapoor, Urvi ; Ayuk, Francis ; Aziz, Mina ; Ben-David, Kaitlyn ; Choe, Hannah K. ; DeFilipp, Zachariah ; Etra, Aaron ; Grupp, Stephan A. ; Hartwell, Matthew J. ; Hexner, Elizabeth O. ; Hogan, William J. ; Karol, Alexander B. ; Kasikis, Stelios ; Kitko, Carrie L. ; Kowalyk, Steven ; Lin, Jung-Yi ; Major-Monfried, Hannah ; Mielke, Stephan ; Merli, Pietro ; Morales, George ; Ordemann, Rainer ; Pulsipher, Michael A. ; Qayed, Muna ; Reddy, Pavan ; Reshef, Ran ; Rösler, Wolf ; Sandhu, Karamjeet S. ; Schechter, Tal ; Shah, Jay ; Sigel, Keith ; Weber, Daniela ; Wölfl, Matthias ; Wudhikarn, Kitsada ; Young, Rachel ; Levine, John E. ; Ferrara, James L. M.



Zusammenfassung

The Mount Sinai Acute GVHD International Consortium (MAGIC) algorithm probability (MAP), derived from 2 serum biomarkers, measures damage to crypts in the gastrointestinal tract during graft-versus-host disease (GVHD). We hypothesized that changes in MAP after treatment could validate it as a response biomarker. We prospectively collected serum samples and clinical stages of acute GVHD from 615 ...

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