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The WW1 Domain Enhances Autoinhibition in Smurf Ubiquitin Ligases

Ruetalo, Natalia ; Anders, Samira ; Stollmaier, Carsten ; Jäckl, Magnus ; Schütz-Stoffregen, Mira C. ; Stefan, Nadine ; Wolf, Christine ; Wiesner, Silke


Downregulation of ubiquitin (Ub) ligase activity prevents premature ubiquitination and is critical for cellular homeostasis. Nedd4 Ub ligases share a common domain architecture and yet are regulated in distinct ways through interactions of the catalytic HECT domain with the N-terminal C2 domain or the central WW domain region. Smurf1 and Smurf2 are two highly related Nedd4 ligases with similar to ...


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