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Osteoprotective action of low-salt diet requires myeloid cell–derived NFAT5

Schröder, Agnes ; Neubert, Patrick ; Titze, Jens ; Bozec, Aline ; Neuhofer, Wolfgang ; Proff, Peter ; Kirschneck, Christian ; Jantsch, Jonathan



Abstract

Dietary salt consumption leads to cutaneous Na+ storage and is associated with various disorders, including osteopenia. Here, we explore the impact of Na+ and the osmoprotective transcription factor nuclear factor of activated T cell 5 (NFAT5) on bone density and osteoclastogenesis. Compared with treatment of mice with high-salt diet, low-salt diet (LSD) increased bone density, decreased ...

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