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Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

Marin, Eros ; Bouchet-Delbos, Laurence ; Renoult, Ophélie ; Louvet, Cédric ; Nerriere-Daguin, Véronique ; Managh, Amy J. ; Even, Amandine ; Giraud, Matthieu ; Vu Manh, Thien Phong ; Aguesse, Audrey ; Bériou, Gaelle ; Chiffoleau, Elise ; Alliot-Licht, Brigitte ; Prieur, Xavier ; Croyal, Mikael ; Hutchinson, James A. ; Obermajer, Natasa ; Geissler, Edward K. ; Vanhove, Bernard ; Blancho, Gilles ; Dalod, Marc ; Josien, Régis ; Pecqueur, Claire ; Cuturi, Maria-Cristina ; Moreau, Aurelie



Zusammenfassung

Cell therapy is a promising strategy for treating patients suffering from autoimmune or inflammatory diseases or receiving a transplant. Based on our preclinical studies, we have generated human autologous tolerogenic dendritic cells (ATDCs), which are being tested in a first-in-man clinical trial in kidney transplant recipients. Here, we report that ATDCs represent a unique subset of ...

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