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A comparison of methods for adapting $^{177}{\rm Lu}$ dose-voxel-kernels to tissue inhomogeneities

Götz, Th. ; Schmidkonz, C. ; Lang, E. W. ; Maier, A. ; Kuwert, T. ; Ritt, P.



Abstract

In-177 Lu radionuclide therapies, dosimetry is used for determining patient-individual dose burden. Standard approaches provide whole organ doses only. For assessing dose heterogeneity inside organs, voxel-wise dosimetry based on 3D SPECT/CT imaging could be applied. Often, this is achieved by convolving voxel-wise time-activity-curves with appropriate dose-voxel-kernels (DVK). The DVKs are meant ...

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