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Tumor-Specific Regulatory T Cells from the Bone Marrow Orchestrate Antitumor Immunity in Breast Cancer

Ge, Yingzi ; Böhm, Hans-Henning ; Rathinasamy, Anchana ; Xydia, Maria ; Hu, Xiaoying ; Pincha, Mudita ; Umansky, Ludmila ; Breyer, Christopher ; Hillier, Michael ; Bonertz, Andreas ; Sevko, Alexandra ; Domschke, Christoph ; Schuetz, Florian ; Frebel, Helge ; Dettling, Steffen ; Herold-Mende, Christel ; Reissfelder, Christoph ; Weitz, Jürgen ; Umansky, Viktor ; Beckhove, Philipp


Endogenous antitumor effector T-cell responses and immune-suppressive regulatory T cells (Treg) critically influence the prognosis of patients with cancer, yet many of the mechanisms of how this occurs remain unresolved. On the basis of an analysis of the function, antigen specificity, and distribution of tumor antigen-reactive T cells and Tregs in patients with breast cancer and transgenic mouse ...


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