Liu, David ; Schilling, Bastian 
; Liu, Derek ; Sucker, Antje ; Livingstone, Elisabeth ; Jerby-Arnon, Livnat ; Zimmer, Lisa ; Gutzmer, Ralf ; Satzger, Imke ; Loquai, Carmen ; Grabbe, Stephan ; Vokes, Natalie ; Margolis, Claire A. ; Conway, Jake ; He, Meng Xiao ; Elmarakeby, Haitham ; Dietlein, Felix ; Miao, Diana ; Tracy, Adam ; Gogas, Helen ; Goldinger, Simone M. ; Utikal, Jochen ; Blank, Christian U. ; Rauschenberg, Ricarda ; von Bubnoff, Dagmar ; Krackhardt, Angela ; Weide, Benjamin ; Haferkamp, Sebastian ; Kiecker, Felix ; Izar, Ben ; Garraway, Levi ; Regev, Aviv ; Flaherty, Keith ; Paschen, Annette ; Van Allen, Eliezer M. ; Schadendorf, Dirk
; Liu, Derek ; Sucker, Antje ; Livingstone, Elisabeth ; Jerby-Arnon, Livnat ; Zimmer, Lisa ; Gutzmer, Ralf ; Satzger, Imke ; Loquai, Carmen ; Grabbe, Stephan ; Vokes, Natalie ; Margolis, Claire A. ; Conway, Jake ; He, Meng Xiao ; Elmarakeby, Haitham ; Dietlein, Felix ; Miao, Diana ; Tracy, Adam ; Gogas, Helen ; Goldinger, Simone M. ; Utikal, Jochen ; Blank, Christian U. ; Rauschenberg, Ricarda ; von Bubnoff, Dagmar ; Krackhardt, Angela ; Weide, Benjamin ; Haferkamp, Sebastian ; Kiecker, Felix ; Izar, Ben ; Garraway, Levi ; Regev, Aviv ; Flaherty, Keith ; Paschen, Annette ; Van Allen, Eliezer M. ; Schadendorf, Dirk 
Zusammenfassung
Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome and whole-transcriptome sequencing of pre-treatment tumors. We found that tumor mutational burden as ...
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