Melum, Espen 
; Jiang, Xiaojun ; Baker, Kristi D. ; Macedo, M. Fatima ; Fritsch, Jürgen ; Dowds, C. Marie ; Wang, Jing ; Pharo, Anne ; Kaser, Arthur ; Tan, Corey ; Pereira, Catia S. ; Kelly, Samuel L. ; Duan, Jingjing ; Karlsen, Tom H. ; Exley, Mark A. ; Schütze, Stefan ; Zajonc, Dirk M. ; Merrill, Alfred H. ; Schuchman, Edward H. ; Zeissig, Sebastian ; Blumberg, Richard S.
; Jiang, Xiaojun ; Baker, Kristi D. ; Macedo, M. Fatima ; Fritsch, Jürgen ; Dowds, C. Marie ; Wang, Jing ; Pharo, Anne ; Kaser, Arthur ; Tan, Corey ; Pereira, Catia S. ; Kelly, Samuel L. ; Duan, Jingjing ; Karlsen, Tom H. ; Exley, Mark A. ; Schütze, Stefan ; Zajonc, Dirk M. ; Merrill, Alfred H. ; Schuchman, Edward H. ; Zeissig, Sebastian ; Blumberg, Richard S. 
Abstract
Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids, such as sphingomyelin. We hypothesized that these serve as endogenous regulators and investigated humans and mice deficient in acid sphingomyelinase (ASM), an enzyme that degrades sphingomyelin. We show that ASM absence in mice leads to diminished ...
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