Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages

Crauwels, Peter ; Bank, Elena ; Walber, Bianca ; Wenzel, Ulf Alexander ; Agerberth, Birgitta ; Chanyalew, Menberework ; Abebe, Markos ; König, Renate ; Ritter, Uwe ; Reiling, Norbert ; van Zandbergen, Ger

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In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of the human cathelicidin CAMP in skin lesions of Ethiopian patients with cutaneous leishmaniasis. Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms. Recombinant cathelicidin was ...