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Haploidentical CD3 or α/β T-cell depleted HSCT in advanced stage sickle cell disease

Foell, Juergen ; Schulte, Johannes H ; Pfirstinger, Beatrix ; Troeger, Anja ; Wolff, Daniel ; Edinger, Matthias ; Hofmann, Petra ; Aslanidis, Charalampos ; Lang, Peter ; Holler, Ernst ; Eggert, Angelika ; Corbacioglu, Selim


Despite significant improvements in the supportive care, sickle cell disease (SCD) leads to significant morbidity and mortality. Allogeneic hematopoietic stem cell transplantation (HSCT), the only curative option, is limited due to matched donor availability. This could be met with T-cell-depleted haploidentical HSCT. Twenty advanced-stage SCD patients, median age 15 years, and 9 patients, median ...


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