Hyaluronidase enhances the activity of adriamycin in breast cancer models in vitro and in vivo

URN to cite this document:: urn:nbn:de:bvb:355-epub-48092
DOI to cite this document:: 10.5283/epub.4809

Beckenlehner, Karin ; Bannke, Silke ; Spruss, Thilo ; Bernhardt, Günther ; Schönenberger, Helmut ; Schiess, Wilfried

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Date of publication of this fulltext: 01 Feb 2012 13:50

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Abstract

The effect of hyaluronidase and a combination of hyaluronidase with Adriamycin was investigated on several breast cancer models in vitro and in vivo. In vitro enzyme treatment (using concentrations up to 80,000 IU/1) of murine (MXT-, MXT +/-, and MXT+) and human (MCF-7, ZR-75-1 and T-47-D) breast cancer cell lines did not inhibit tumour cell proliferation (measured by a kinetic crystal violet ...