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The mTORC2‐Akt1 Cascade Is Crucial for c‐Myc to Promote Hepatocarcinogenesis in Mice and Humans

Xu, Zhong ; Xu, Meng ; Liu, Pin ; Zhang, Shu ; Shang, Runze ; Qiao, Yu ; Che, Li ; Ribback, Silvia ; Cigliano, Antonio ; Evert, Katja ; Pascale, Rosa M. ; Dombrowski, Frank ; Evert, Matthias ; Chen, Xi ; Calvisi, Diego F. ; Chen, Xin



Abstract

Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. The c-Myc transcription factor is a pivotal player in hepatocarcinogenesis, but the mechanisms underlying c-Myc oncogenic activity in the liver remain poorly delineated. Mammalian target of rapamycin complex 2 (mTORC2) has been implicated in cancer by regulating multiple AGC kinases, especially AKT ...

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