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Comparing everolimus‐based immunosuppression with reduction or withdrawal of calcineurin inhibitor reduction from 6 months after heart transplantation: The randomized MANDELA study

Barten, Markus J. ; Hirt, Stephan W. ; Garbade, Jens ; Bara, Christoph ; Doesch, Andreas O. ; Knosalla, Christoph ; Grinninger, Carola ; Stypmann, Jörg ; Sieder, Christian ; Lehmkuhl, Hans B. ; Porstner, Martina ; Schulz, Uwe ; Deuse, Tobias ; Costard‐Jaeckle, Angelika ; Sill, Björn ; Haneya, Assad ; Eifert, Sandra ; Kaczmarek, Ingo ; Eickmeyer, Holm ; Hiemann, Nicola ; Kemper, Dagmar



Abstract

In the 12-month, open-label MANDELA study, patients were randomized at month 6 after heart transplantation to (1) convert to calcineurin inhibitor (CNI)-free immunosuppression with everolimus (EVR), mycophenolic acid and steroids (CNI-free, n = 71), or to (2) continue reduced-exposure CNI, with EVR and steroids (EVR/redCNI, n = 74). Tacrolimus was administered in 48.8% of EVR/redCNI patients and ...

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