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Effects of closed-loop automatic control of the inspiratory fraction of oxygen (FiO2-C) on outcome of extremely preterm infants – study protocol of a randomized controlled parallel group multicenter trial for safety and efficacy

Maiwald, Christian A. ; Niemarkt, Hendrik J. ; Poets, Christian F. ; Urschitz, Michael S. ; König, Jochem ; Hummler, Helmut ; Bassler, Dirk ; Engel, Corinna ; Franz, Axel R.



Zusammenfassung

Background Most extremely low gestational age neonates (ELGANS, postmenstrual age at birth (PMA) < 28 completed weeks) require supplemental oxygen and experience frequent intermittent hypoxemic and hyperoxemic episodes. Hypoxemic episodes and exposure to inadequately high concentrations of oxygen are associated with an increased risk of retinopathy of prematurity (ROP), chronic lung disease of ...

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