[1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. II. Synthesis and preliminary testing of the enantiomeric complexes

URN to cite this document:

urn:nbn:de:bvb:355-epub-48143 Copy

DOI to cite this document:

10.5283/epub.4814 Copy

Bernhardt, Günther ; Gust, Ronald ; Reile, Herta ; vom Orde, Hans Dieter ; Müller, Richard ; Keller, Christoph ; Spruß, Thilo ; Schönenberger, Helmut ; Burgemeister, Thomas ; Mannschreck, Albrecht ; Range, Klaus-Jürgen ; Klement, Ulrich

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Date of publication of this fulltext: 05 Aug 2009 13:48

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Details

Item type:	Article
Journal or Publication Title:	Journal of cancer research and clinical oncology
Volume:	118
Number of Issue or Book Chapter:	3
Page Range:	pp. 201-208
Date:	1992
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects (Historical):	SFB 234
Identification Number:	Value Type 1548285 PubMed ID
Classification:	Notation Type Adenocarcinoma/drug therapy MESH Antineoplastic Agents/chemical synthesis MESH Chromosome Aberrations MESH Female MESH Humans MESH Molecular Conformation MESH Organoplatinum Compounds/chemical synthesis MESH Ovarian Neoplasms/drug therapy MESH Stereoisomerism MESH Tumor Cells, Cultured/drug effects MESH
Dewey Decimal Classification:	500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	4814

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Abstract

The enantiomeric [1,2-bis(2-hydroxyphenyl)-ethylenediamine]dichloroplatinum(II) complexes were synthesized and their configuration assessed. A preliminary test in the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line, which was previously characterized by its sensitivity against several therapeutically used drugs, showed that both enantiomers produce cytocidal effects in a ...

Abstract

The enantiomeric [1,2-bis(2-hydroxyphenyl)-ethylenediamine]dichloroplatinum(II) complexes were synthesized and their configuration assessed. A preliminary test in the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line, which was previously characterized by its sensitivity against several therapeutically used drugs, showed that both enantiomers produce cytocidal effects in a concentration of 2.5 microM. A difference between the enantiomers became evident from the faster onset of cytocidal activity of the S,S-configurated compound.

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Metadata last modified: 26 Nov 2020 15:48

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