Dichloro-[1-(hydroxyphenyl)-2-phenylethylenediamine]platinum(II) complexes: testing on the human ovarian cancer cell lines NIH: OVCAR3 and SK OV 3

URN to cite this document:: urn:nbn:de:bvb:355-epub-48188
DOI to cite this document:: 10.5283/epub.4818

Bernhardt, Günther ; Müller, Richard ; Gust, Ronald ; Reile, Herta ; Keller, Christoph ; Spruss, Thilo ; Schönenberger, Helmut

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Date of publication of this fulltext: 05 Aug 2009 13:48

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Abstract

The diastereoisomeric dichloro-[1-(2-, 3- and 4-hydroxyphenyl)-2-phenylethylenediamine]platinum(II) complexes were tested on two human ovarian cancer cell lines NIH: OVCAR-3 and SK-OV-3, both resistant against cisplatin. Dichloro-[threo-1-(3-hydroxyphenyl)-2-phenylethylenediamine]platinum(II) (threo-5-PtCl2) proved to be the most active representative of the new series, producing cytocidal ...