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The neuropathology of fatal encephalomyelitis in human Borna virus infection

Liesche, Friederike ; Ruf, Viktoria ; Zoubaa, Saida ; Kaletka, Gwendolyn ; Rosati, Marco ; Rubbenstroth, Dennis ; Herden, Christiane ; Goehring, Lutz ; Wunderlich, Silke ; Wachter, Miguel Frederic ; Rieder, Georg ; Lichtmannegger, Ines ; Permanetter, Willibald ; Heckmann, Josef G. ; Angstwurm, Klemens ; Neumann, Bernhard ; Märkl, Bruno ; Haschka, Stefan ; Niller, Hans-Helmut ; Schmidt, Barbara ; Jantsch, Jonathan ; Brochhausen, Christoph ; Schlottau, Kore ; Ebinger, Arnt ; Hemmer, Bernhard ; Riemenschneider, Markus J. ; Herms, Jochen ; Beer, Martin ; Matiasek, Kaspar ; Schlegel, Jürgen



Abstract

After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with ...

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