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[DL-1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer

Müller, Richard, Gust, Ronald, Bernhardt, Günther, Keller, Christoph, Schönenberger, Helmut, Seeber, Siegfried, Osieka, Reinhardt, Eastman, Alan and Jennerwein, Margaretha (1990) [DL-1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. Journal of cancer research and clinical oncology 116 (3), pp. 237-244.

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Abstract

The synthesis of diastereoisomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes, DL-3-PtCl2 and meso-3-PtCl2, and their evaluation on the hormone-independent, human MDA-MB231 breast cancer cell line, on the cisplatin-sensitive and -resistant L1210 leukemia cell line, on the cisplatin-resistant human NIH:OVCAR 3 ovarian cancer cell line, on the P-388 leukemia of the ...

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Item type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
2370248PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Carcinoma, Ehrlich Tumor/drug therapyMESH
Cisplatin/pharmacologyMESH
Drug ResistanceMESH
FemaleMESH
HumansMESH
MiceMESH
Organoplatinum Compounds/pharmacologyMESH
Ovarian Neoplasms/drug therapyMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4829
Owner only: item control page

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