[DL-1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer

URN to cite this document:: urn:nbn:de:bvb:355-epub-48298
DOI to cite this document:: 10.5283/epub.4829

Müller, Richard ; Gust, Ronald ; Bernhardt, Günther ; Keller, Christoph ; Schönenberger, Helmut ; Seeber, Siegfried ; Osieka, Reinhardt ; Eastman, Alan ; Jennerwein, Margaretha

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Date of publication of this fulltext: 05 Aug 2009 13:48

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Abstract

The synthesis of diastereoisomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes, DL-3-PtCl2 and meso-3-PtCl2, and their evaluation on the hormone-independent, human MDA-MB231 breast cancer cell line, on the cisplatin-sensitive and -resistant L1210 leukemia cell line, on the cisplatin-resistant human NIH:OVCAR 3 ovarian cancer cell line, on the P-388 leukemia of the ...