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Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

Hellwege, Jacklyn N. ; Velez Edwards, Digna R. ; Giri, Ayush ; Qiu, Chengxiang ; Park, Jihwan ; Torstenson, Eric S. ; Keaton, Jacob M. ; Wilson, O. D. ; Robinson-Cohen, Cassianne ; Chung, Cecilia P. ; Roumie, Christianne L. ; Klarin, Derek ; Damrauer, Scott M. ; DuVall, Scott L. ; Siew, Edward ; Akwo, Elvis A. ; Wuttke, Matthias ; Gorski, Mathias ; Li, Man ; Li, Yong ; Gaziano, J. Michael ; Wilson, Peter W. F. ; Tsao, Philip S. ; O’Donnell, Christopher J. ; Kovesdy, Csaba P. ; Pattaro, Cristian ; Köttgen, Anna ; Susztak, Katalin ; Edwards, Todd L. ; Hung, Adriana M.



Abstract

Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide Association Study of eGFR in 280,722 participants of the Million Veteran Program (MVP), with replication in 765,289 participants from the Chronic Kidney Disease Genetics (CKDGen) Consortium. We identify 82 previously ...

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