Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes, III: Evaluation of the mammary tumor inhibiting properties

URN to cite this document:: urn:nbn:de:bvb:355-epub-48343
DOI to cite this document:: 10.5283/epub.4834

Reile, Herta ; Spruß, Thilo ; Müller, Richard ; Gust, Ronald ; Bernhardt, Günther ; Schönenberger, Helmut ; Engel, Jürgen

Preview

PDF
(493kB)

Date of publication of this fulltext: 05 Aug 2009 13:48

Alternative links to fulltext:Pubmed

Details

Preview

Export bibliographical data

Abstract

Diastereomeric diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates produce a strong inhibition of the hormone-dependent MXT-M 3.2 mammary carcinoma of the B6D2F1 mouse. Besides an interference in the DNA synthesis in analogy to cisplatin a lowering of the estrogen level due to an interference in steroid biosynthesis is suggested as the mode of action. In contrast to ...