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1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties

Schertl, Sabine ; Hartmann, Rolf W. ; Batzl-Hartmann, Christine ; Schlemmer, Richard ; Spruß, Thilo ; Bernhardt, Günther ; Gust, Ronald ; Schönenberger, Helmut



Abstract

[meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL'; L,L' = Cl or L = H2O and L' = OSO3) are highly effective towards hormone-sensitive, rodent breast cancers due to their significant estrogenic potencies. Their antitumor activities are caused by modification of the immune response. The pharmacophor of these compounds, the ...

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