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Nonglucuronidated Ezetimibe Disrupts CD13‐ and CD64‐Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages

Orsó, Evelyn ; Robenek, Horst ; Boettcher, Alfred ; Wolf, Zsuzsanna ; Liebisch, Gerhard ; Kramer, Werner ; Schmitz, Gerd


Ezetimibe (EZE) and glucuronidated EZE (EZE-Glu) differentially target Niemann-Pick C1-like 1 (NPC1L1) and CD13 (aminopeptidase-N) to inhibit intestinal cholesterol absorption and cholesterol processing in other cells, although the precise molecular mechanisms are not fully elucidated. Cellular effects of EZE, EZE-Glu, and the low-absorbable EZE-analogue S6130 were investigated on human ...


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