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Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury

Morace, Ivan ; Pilz, Robert ; Federico, Giuseppina ; Jennemann, Richard ; Krunic, Damir ; Nordström, Viola ; von Gerichten, Johanna ; Marsching, Christian ; Schießl, Ina Maria ; Müthing, Johannes ; Wunder, Christian ; Johannes, Ludger ; Sandhoff, Roger ; Gröne, Hermann-Josef


To elucidate the physiologic function of renal globotriaosylceramide (Gb3/CD77), which up-to-date has been associated exclusively with Shiga toxin binding, we have analyzed renal function in Gb3-deficient mice. Gb3 synthase KO (Gb3S(-/-)) mice displayed an increased renal albumin and low molecular weight protein excretion compared to WT. Gb3 localized at the brush border and within vesicular ...


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