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Antitumour activity of miltefosine alone and after combination with platinum complexes on MXT mouse mammary carcinoma models

URN to cite this document:
urn:nbn:de:bvb:355-epub-48442
Spruß, Thilo ; Bernhardt, Günther ; Schönenberger, Helmut ; Engel, Jürgen
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Date of publication of this fulltext: 05 Aug 2009 13:48


Abstract

Miltefosine, an alkylphosphocholine structurally related to alkyllysophospholipids showed highly selective antitumour activity against the hormone-sensitive variant of the s.c. transplantable MXT mouse mammary adenocarcinoma, the ovary-dependent MXT (M3.2), whereas it was inactive against the hormone-insensitive MXT (M3.2) OVEX variant. A dose of 32 mg/kg miltefosine p.o. daily for 5 weeks was ...

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