Antitumour activity of miltefosine alone and after combination with platinum complexes on MXT mouse mammary carcinoma models

URN to cite this document:: urn:nbn:de:bvb:355-epub-48442
DOI to cite this document:: 10.5283/epub.4844

Spruß, Thilo ; Bernhardt, Günther ; Schönenberger, Helmut ; Engel, Jürgen

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Date of publication of this fulltext: 05 Aug 2009 13:48

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Abstract

Miltefosine, an alkylphosphocholine structurally related to alkyllysophospholipids showed highly selective antitumour activity against the hormone-sensitive variant of the s.c. transplantable MXT mouse mammary adenocarcinoma, the ovary-dependent MXT (M3.2), whereas it was inactive against the hormone-insensitive MXT (M3.2) OVEX variant. A dose of 32 mg/kg miltefosine p.o. daily for 5 weeks was ...