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Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome

Larionov, Alexey ; Dahlke, Eileen ; Kunke, Madlen ; Zanon Rodriguez, Luis ; Schiessl, Ina M. ; Magnin, Jean‐Luc ; Kern, Ursula ; Alli, Abdel A. ; Mollet, Geraldine ; Schilling, Oliver ; Castrop, Hayo ; Theilig, Franziska



Abstract

The NPHS2 gene, encoding the slit diaphragm protein podocin, accounts for genetic and sporadic forms of nephrotic syndrome (NS). Patients with NS often present symptoms of volume retention, such as oedema formation or hypertension. The primary dysregulation in sodium handling involves an inappropriate activation of the epithelial sodium channel, ENaC. Plasma proteases in a proteinuria-dependent ...

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