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Hyaluronidase significantly enhances the efficacy of regional vinblastine chemotherapy of malignant melanoma

Spruß, Thilo ; Bernhardt, Günther ; Schönenberger, Helmut ; Schiess, Wilfried


The regional chemotherapy of the human malignant melanomas (SK-MEL-2, -3, -5, -24) implanted in NMRI nu/nu mice with a combination of the hyaluronic-acid-cleaving enzyme hyaluronidase (HYase) and vinblastine is a very effective therapeutic procedure. In three out of four melanoma models (SK-MEL-2, -3, -5) the weekly peritumoral administration of high-dose HYase (100,000 IU/kg) 4 h prior to the ...


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