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Hyaluronidase significantly enhances the efficacy of regional vinblastine chemotherapy of malignant melanoma

Spruß, Thilo, Bernhardt, Günther, Schönenberger, Helmut and Schiess, Wilfried (1995) Hyaluronidase significantly enhances the efficacy of regional vinblastine chemotherapy of malignant melanoma. Journal of cancer research and clinical oncology 121 (4), pp. 193-202.

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The regional chemotherapy of the human malignant melanomas (SK-MEL-2, -3, -5, -24) implanted in NMRI nu/nu mice with a combination of the hyaluronic-acid-cleaving enzyme hyaluronidase (HYase) and vinblastine is a very effective therapeutic procedure. In three out of four melanoma models (SK-MEL-2, -3, -5) the weekly peritumoral administration of high-dose HYase (100,000 IU/kg) 4 h prior to the ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
7751317PubMed ID
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Cell Division/drug effectsMESH
Chemotherapy, Cancer, Regional PerfusionMESH
Dose-Response Relationship, DrugMESH
Drug SynergismMESH
Hyaluronoglucosaminidase/administration & dosageMESH
Injections, IntraperitonealMESH
Injections, SubcutaneousMESH
Melanoma/drug therapyMESH
Mice, NudeMESH
Neoplasm TransplantationMESH
Tumor Cells, Cultured/drug effectsMESH
Vinblastine/administration & dosageMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4845
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