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Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes

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vom Orde, Hans Dieter ; Reile, Herta ; Müller, Richard ; Gust, Ronald ; Bernhardt, Günther ; Spruß, Thilo ; Schönenberger, Helmut ; Burgemeister, Thomas ; Mannschreck, Albrecht
Date of publication of this fulltext: 05 Aug 2009 13:48


The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.

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