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Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes

vom Orde, Hans Dieter, Reile, Herta, Müller, Richard, Gust, Ronald, Bernhardt, Günther, Spruß, Thilo, Schönenberger, Helmut, Burgemeister, Thomas and Mannschreck, Albrecht (1990) Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. Journal of cancer research and clinical oncology 116 (5), pp. 434-438.

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Abstract

The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.


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Item type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Prof.Dr. Mannschreck
Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2229132PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/therapeutic useMESH
Body Weight/drug effectsMESH
Breast Neoplasms/drug therapyMESH
Cisplatin/therapeutic useMESH
HumansMESH
Leukemia P388/drug therapyMESH
MiceMESH
Mice, Inbred DBAMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organoplatinum Compounds/therapeutic useMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4846
Owner only: item control page

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