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Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy

van Bruggen, Jaco A. C. ; Martens, Anne W. J. ; Fraietta, Joseph A. ; Hofland, Tom ; Tonino, Sanne H. ; Eldering, Eric ; Levin, Mark-David ; Siska, Peter J. ; Endstra, Sanne ; Rathmell, Jeffrey C. ; June, Carl H. ; Porter, David L. ; Melenhorst, J. Joseph ; Kater, Arnon P. ; van der Windt, Gerritje J. W.


In chronic lymphocytic leukemia (CLL), acquired T-cell dysfunction impedes development of effective immunotherapeutic strategies, through as-yet unresolved mechanisms. We have previously shown that CD8(+) T cells in CLL exhibit impaired activation and reduced glucose uptake after stimulation. CD8(+) T cells in CLL patients are chronically exposed to leukemic B cells, which potentially impacts ...


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