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Komplexität von PEComen

Utpatel, K. ; Calvisi, D. F. ; Köhler, G. ; Kühnel, T. ; Niesel, A. ; Verloh, N. ; Vogelhuber, M. ; Neu, R. ; Hosten, N. ; Schildhaus, H.-U. ; Dietmaier, W. ; Evert, M.


Perivascular epithelioid cell neoplasms (PEComas) are afamily of mesenchymal neoplasms with features of both melanotic and smooth muscle differentiation. PEComa morphology is highly variable and encompasses epithelioid to spindle cells often with clear cytoplasm and prominent nucleoli. Molecularly, most PEComas are defined by aloss of function of the TSC1/TSC2 complex. Additionally, adistinct ...


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