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Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

Urdinguio, Rocio G. ; Lopez, Virginia ; Bayón, Gustavo F. ; Diaz de la Guardia, Rafael ; Sierra, Marta I. ; García-Toraño, Estela ; Perez, Raúl F. ; García, María G. ; Carella, Antonella ; Pruneda, Patricia C. ; Prieto, Cristina ; Dmitrijeva, Marija ; Santamarina, Pablo ; Belmonte, Thalía ; Mangas, Cristina ; Diaconu, Elena ; Ferrero, Cecilia ; Tejedor, Juan Ramón ; Fernandez-Morera, Juan Luis ; Bravo, Cristina ; Bueno, Clara ; Sanjuan-Pla, Alejandra ; Rodriguez, Ramon M. ; Suarez-Alvarez, Beatriz ; López-Larrea, Carlos ; Bernal, Teresa ; Colado, Enrique ; Balbín, Milagros ; García-Suarez, Olivia ; Chiara, María Dolores ; Sáenz-de-Santa-María, Inés ; Rodríguez, Francisco ; Pando-Sandoval, Ana ; Rodrigo, Luis ; Santos, Laura ; Salas, Ana ; Vallejo-Díaz, Jesús ; Carrera, Ana C. ; Rico, Daniel ; Hernández-López, Inmaculada ; Vayá, Amparo ; Ricart, José M. ; Seto, Edward ; Sima-Teruel, Núria ; Vaquero, Alejandro ; Valledor, Luis ; Cañal, Maria Jesus ; Pisano, David ; Graña-Castro, Osvaldo ; Thomas, Tim ; Voss, Anne K. ; Menéndez, Pablo ; Villar-Garea, Ana ; Deutzmann, Rainer ; Fernandez, Agustín F. ; Fraga, Mario F.



Abstract

Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally ...

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