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Impact of hydroxyethyl starch and modified fluid gelatin on granulocyte phenotype and function

Doblinger, Nina ; Bredthauer, Andre ; Mohrez, Morad ; Hähnel, Viola ; Graf, Bernhard ; Gruber, Michael ; Ahrens, Norbert


BACKGROUND Patients with neutropenia or granulocyte dysfunction may require granulocyte transfusions for adequate immune restoration. High-molecular-weight hydroxyethyl starch (HES) is the most commonly used sedimentation agent to enhance granulocyte collection efficiency. However, authorities recently restricted the use of HES due to its unfavorable risk-benefit profile. As modified fluid ...


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