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The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Pfannstiel, Carolin ; Strissel, Pamela L. ; Chiappinelli, Katherine B. ; Sikic, Danijel ; Wach, Sven ; Wirtz, Ralph M. ; Wullweber, Adrian ; Taubert, Helge ; Breyer, Johannes ; Otto, Wolfgang ; Worst, Thomas ; Burger, Maximilian ; Wullich, Bernd ; Bolenz, Christian ; Fuhrich, Nicole ; Geppert, Carol I. ; Weyerer, Veronika ; Stoehr, Robert ; Bertz, Simone ; Keck, Bastian ; Erlmeier, Franziska ; Erben, Philipp ; Hartmann, Arndt ; Strick, Reiner ; Eckstein, Markus


Muscle-invasive bladder cancer (MIBC) represents approximately two-thirds of invasive urothelial bladder cancers (UBC) and has high morbidity and mortality. Men are over 3-fold more frequently affected by UBC than women. Despite intensive efforts to improve patient treatment and outcome, two-thirds of patients with UBC will have a recurrence or disease progression within 5 years. We demonstrated ...


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