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Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system

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Ilyaskin, Alexandr V. ; Sure, Florian ; Nesterov, Viatcheslav ; Haerteis, Silke ; Korbmacher, Christoph
Date of publication of this fulltext: 03 Sep 2021 10:01


We recently demonstrated that bile acids, especially tauro-deoxycholic acid (t-DCA), modify the function of the acid-sensing ion channel ASIC1a and other members of the epithelial sodium channel (ENaC)/degenerin (DEG) ion channel family. Surprisingly, ASIC1 shares a high degree of structural similarity with the purinergic receptor P2X4, a nonselective cation channel transiently activated by ATP. ...


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