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Efficacy of high-frequency repetitive transcranial magnetic stimulation in schizophrenia patients with treatment-resistant negative symptoms treated with clozapine

Wagner, Elias ; Wobrock, Thomas ; Kunze, Birgit ; Langguth, Berthold ; Landgrebe, Michael ; Eichhammer, Peter ; Frank, Elmar ; Cordes, Joachim ; Wölwer, Wolfgang ; Winterer, Georg ; Gaebel, Wolfgang ; Hajak, Göran ; Ohmann, Christian ; Verde, Pablo E. ; Rietschel, Marcella ; Ahmed, Raees ; Honer, William G. ; Siskind, Dan ; Malchow, Berend ; Strube, Wolfgang ; Schneider-Axmann, Thomas ; Falkai, Peter ; Hasan, Alkomiet



Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising augmentation treatment for schizophrenia, however there are few controlled studies of rTMS augmentation of clozapine. Methods: Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we examined the impact of rTMS on PANSS total, general, positive and negative symptoms among ...

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