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Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy

Fröb, Franziska ; Sock, Elisabeth ; Tamm, Ernst. R. ; Saur, Anna-Lena ; Hillgärtner, Simone ; Williams, Trevor J. ; Fujii, Toshihiro ; Fukunaga, Rikiro ; Wegner, Michael



Abstract

Schwann cells ensure efficient nerve impulse conduction in the peripheral nervous system. Their development is accompanied by defined chromatin changes, including variant histone deposition and redistribution. To study the importance of variant histones for Schwann cell development, we altered their genomic distribution by conditionally deleting Ep400, the central subunit of the Tip60/Ep400 ...

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