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Plasma membrane–localized TMEM16 proteins are indispensable for expression of CFTR

Benedetto, Roberta ; Ousingsawat, Jiraporn ; Cabrita, Inês ; Pinto, Madalena ; Lérias, Joana R. ; Wanitchakool, Podchanart ; Schreiber, Rainer ; Kunzelmann, Karl


The cystic fibrosis transmembrane conductance regulator (CFTR) is the secretory chloride channel in epithelial tissues that has a central role in cystic fibrosis (CF) lung and gastrointestinal disease. A recent publication demonstrates a close association between CFTR and TMEM16A, the calcium-activated chloride channel. Thus, no CFTR chloride currents could be detected in airways and large ...


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