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Oligodendroglial α‐synucleinopathy‐driven neuroinflammation in multiple system atrophy

Hoffmann, Alana ; Ettle, Benjamin ; Battis, Kristina ; Reiprich, Simone ; Schlachetzki, Johannes C. M. ; Masliah, Eliezer ; Wegner, Michael ; Kuhlmann, Tanja ; Riemenschneider, Markus J. ; Winkler, Jürgen



Abstract

Neuroinflammation and oligodendroglial cytoplasmic alpha-synuclein (alpha-syn) inclusions (GCIs) are important neuropathological characteristics of multiple system atrophy (MSA). GCIs are known to interfere with oligodendroglial maturation and consequently result in myelin loss. The neuroinflammatory phenotype in the context of MSA, however, remains poorly understood. Here, we demonstrate ...

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