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L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

Errasti-Murugarren, Ekaitz ; Fort, Joana ; Bartoccioni, Paola ; Díaz, Lucía ; Pardon, Els ; Carpena, Xavier ; Espino-Guarch, Meritxell ; Zorzano, Antonio ; Ziegler, Christine ; Steyaert, Jan ; Fernández-Recio, Juan ; Fita, Ignacio ; Palacín, Manuel


L-amino acid transporters (LATs) play key roles in human physiology and are implicated in several human pathologies. LATs are asymmetric amino acid exchangers where the low apparent affinity cytoplasmic side controls the exchange of substrates with high apparent affinity on the extracellular side. Here, we report the crystal structures of an LAT, the bacterial alanine-serine-cysteine exchanger ...


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