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Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators

Woloszynska, Magdalena ; Le Gall, Sabine ; Neyt, Pia ; Boccardi, Tommaso M. ; Grasser, Marion ; Längst, Gernot ; Aesaert, Stijn ; Coussens, Griet ; Dhondt, Stijn ; Van De Slijke, Eveline ; Bruno, Leonardo ; Fung-Uceda, Jorge ; Mas, Paloma ; Van Montagu, Marc ; Inzé, Dirk ; Himanen, Kristiina ; De Jaeger, Geert ; Grasser, Klaus D. ; Van Lijsebettens, Mieke



Abstract

HISTONE MONOUBIQUITINATION1 (HUB1) and its paralog HUB2 act in a conserved heterotetrameric complex in the chromatinmediated transcriptional modulation of developmental programs, such as flowering time, dormancy, and the circadian clock. The KHD1 and SPEN3 proteins were identified as interactors of the HUB1 and HUB2 proteins with in vitro RNA-binding activity. Mutants in SPEN3 and KHD1 had ...

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