Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Nature Genetics | ||||
Verlag: | NATURE PUBLISHING GROUP | ||||
Ort der Veröffentlichung: | NEW YORK | ||||
Band: | 51 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 4 | ||||
Seitenbereich: | S. 636-648 | ||||
Datum: | 2019 | ||||
Institutionen: | Medizin > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | ENVIRONMENT INTERACTION; GENOTYPE IMPUTATION; NICOTINE METABOLISM; RISK LOCI; METAANALYSIS; ARCHITECTURE; CHOLESTEROL; CIGARETTES; VARIANTS; SUSCEPTIBILITY; | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 48830 |
Zusammenfassung
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci ...
Zusammenfassung
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Metadaten zuletzt geändert: 03 Sep 2021 10:03