; Sung, Yun J. ; Brown, Michael R. ; Winkler, Thomas W. ; Kraja, Aldi T. ; Ntalla, Ioanna ; Schwander, Karen ; Chasman, Daniel I. ; Lim, Elise ; Deng, Xuan ; Guo, Xiuqing ; Liu, Jingmin ; Lu, Yingchang ; Cheng, Ching-Yu
; Sim, Xueling ; Vojinovic, Dina
; Huffman, Jennifer E. ; Musani, Solomon K. ; Li, Changwei
; Feitosa, Mary F.
; Richard, Melissa A. ; Noordam, Raymond ; Baker, Jenna ; Chen, Guanjie
; Aschard, Hugues ; Bartz, Traci M. ; Ding, Jingzhong ; Dorajoo, Rajkumar ; Manning, Alisa K. ; Rankinen, Tuomo ; Smith, Albert V.
; Tajuddin, Salman M.
; Zhao, Wei ; Graff, Mariaelisa ; Alver, Maris ; Boissel, Mathilde
; Chai, Jin Fang ; Chen, Xu
; Divers, Jasmin ; Evangelou, Evangelos ; Gao, Chuan ; Goel, Anuj
; Hagemeijer, Yanick
; Harris, Sarah E. ; Hartwig, Fernando P. ; He, Meian ; Horimoto, Andrea R. V. R. ; Hsu, Fang-Chi ; Hung, Yi-Jen ; Jackson, Anne U. ; Kasturiratne, Anuradhani ; Komulainen, Pirjo ; Kühnel, Brigitte ; Leander, Karin
; Lin, Keng-Hung ; Luan, Jian’an ; Lyytikäinen, Leo-Pekka ; Matoba, Nana
; Nolte, Ilja M. ; Pietzner, Maik ; Prins, Bram
; Riaz, Muhammad
; Robino, Antonietta ; Said, M. Abdullah
; Schupf, Nicole ; Scott, Robert A. ; Sofer, Tamar
; Stancáková, Alena ; Takeuchi, Fumihiko ; Tayo, Bamidele O. ; van der Most, Peter J. ; Varga, Tibor V.
; Wang, Tzung-Dau ; Wang, Yajuan ; Ware, Erin B. ; Wen, Wanqing ; Xiang, Yong-Bing ; Yanek, Lisa R. ; Zhang, Weihua ; Zhao, Jing Hua ; Adeyemo, Adebowale
; Afaq, Saima ; Amin, Najaf ; Amini, Marzyeh ; Arking, Dan E. ; Arzumanyan, Zorayr ; Aung, Tin ; Ballantyne, Christie ; Barr, R. Graham ; Bielak, Lawrence F. ; Boerwinkle, Eric ; Bottinger, Erwin P. ; Broeckel, Ulrich ; Brown, Morris ; Cade, Brian E.
; Campbell, Archie ; Canouil, Mickaël
; Charumathi, Sabanayagam ; Chen, Yii-Der Ida
; Christensen, Kaare
; Concas, Maria Pina ; Connell, John M. ; de las Fuentes, Lisa
; de Silva, H. Janaka ; de Vries, Paul S. ; Doumatey, Ayo ; Duan, Qing ; Eaton, Charles B. ; Eppinga, Ruben N. ; Faul, Jessica D. ; Floyd, James S. ; Forouhi, Nita G. ; Forrester, Terrence ; Friedlander, Yechiel ; Gandin, Ilaria ; Gao, He ; Ghanbari, Mohsen ; Gharib, Sina A. ; Gigante, Bruna ; Giulianini, Franco ; Grabe, Hans J. ; Gu, C. Charles ; Harris, Tamara B. ; Heikkinen, Sami
; Heng, Chew-Kiat ; Hirata, Makoto ; Hixson, James E. ; Ikram, M. Arfan ; Jia, Yucheng ; Joehanes, Roby ; Johnson, Craig ; Jonas, Jost Bruno ; Justice, Anne E. ; Katsuya, Tomohiro ; Khor, Chiea Chuen ; Kilpeläinen, Tuomas O.
; Koh, Woon-Puay ; Kolcic, Ivana ; Kooperberg, Charles ; Krieger, Jose E. ; Kritchevsky, Stephen B. ; Kubo, Michiaki ; Kuusisto, Johanna ; Lakka, Timo A. ; Langefeld, Carl D. ; Langenberg, Claudia ; Launer, Lenore J. ; Lehne, Benjamin ; Lewis, Cora E. ; Li, Yize
; Liang, Jingjing ; Lin, Shiow ; Liu, Ching-Ti ; Liu, Jianjun ; Liu, Kiang ; Loh, Marie ; Lohman, Kurt K. ; Louie, Tin ; Luzzi, Anna ; Mägi, Reedik ; Mahajan, Anubha ; Manichaikul, Ani W. ; McKenzie, Colin A. ; Meitinger, Thomas ; Metspalu, Andres ; Milaneschi, Yuri ; Milani, Lili ; Mohlke, Karen L. ; Momozawa, Yukihide ; Morris, Andrew P.
; Murray, Alison D. ; Nalls, Mike A. ; Nauck, Matthias ; Nelson, Christopher P. ; North, Kari E. ; O’Connell, Jeffrey R. ; Palmer, Nicholette D. ; Papanicolau, George J. ; Pedersen, Nancy L. ; Peters, Annette ; Peyser, Patricia A. ; Polasek, Ozren
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; Schmidt, Carsten O. ; Schreiner, Pamela J. ; Scott, William R. ; Sever, Peter ; Shi, Yuan ; Sidney, Stephen ; Sims, Mario ; Smith, Jennifer A.
; Snieder, Harold ; Starr, John M. ; Strauch, Konstantin ; Stringham, Heather M. ; Tan, Nicholas Y. Q. ; Tang, Hua ; Taylor, Kent D. ; Teo, Yik Ying ; Tham, Yih Chung ; Tiemeier, Henning
; Turner, Stephen T. ; Uitterlinden, André G. ; van Heemst, Diana ; Waldenberger, Melanie ; Wang, Heming ; Wang, Lan ; Wang, Lihua ; Wei, Wen Bin ; Williams, Christine A. ; Wilson, Gregory ; Wojczynski, Mary K. ; Yao, Jie ; Young, Kristin ; Yu, Caizheng ; Yuan, Jian-Min ; Zhou, Jie ; Zonderman, Alan B. ; Becker, Diane M. ; Boehnke, Michael ; Bowden, Donald W. ; Chambers, John C. ; Cooper, Richard S. ; de Faire, Ulf ; Deary, Ian J. ; Elliott, Paul ; Esko, Tõnu ; Farrall, Martin ; Franks, Paul W. ; Freedman, Barry I. ; Froguel, Philippe ; Gasparini, Paolo ; Gieger, Christian ; Horta, Bernardo L.
; Juang, Jyh-Ming Jimmy ; Kamatani, Yoichiro ; Kammerer, Candace M.
; Kato, Norihiro ; Kooner, Jaspal S. ; Laakso, Markku ; Laurie, Cathy C. ; Lee, I-Te ; Lehtimäki, Terho ; Magnusson, Patrik K. E. ; Oldehinkel, Albertine J. ; Penninx, Brenda W. J. H. ; Pereira, Alexandre C. ; Rauramaa, Rainer ; Redline, Susan ; Samani, Nilesh J. ; Scott, James ; Shu, Xiao-Ou ; van der Harst, Pim ; Wagenknecht, Lynne E. ; Wang, Jun-Sing ; Wang, Ya Xing ; Wareham, Nicholas J. ; Watkins, Hugh ; Weir, David R. ; Wickremasinghe, Ananda R. ; Wu, Tangchun ; Zeggini, Eleftheria ; Zheng, Wei ; Bouchard, Claude
; Evans, Michele K. ; Gudnason, Vilmundur
; Kardia, Sharon L. R. ; Liu, Yongmei ; Psaty, Bruce M. ; Ridker, Paul M. ; van Dam, Rob M.
; Mook-Kanamori, Dennis O. ; Fornage, Myriam ; Province, Michael A. ; Kelly, Tanika N. ; Fox, Ervin R. ; Hayward, Caroline ; van Duijn, Cornelia M. ; Tai, E. Shyong ; Wong, Tien Yin ; Loos, Ruth J. F.
; Franceschini, Nora ; Rotter, Jerome I. ; Zhu, Xiaofeng
; Bierut, Laura J.
; Gauderman, W. James ; Rice, Kenneth ; Munroe, Patricia B. ; Morrison, Alanna C. ; Rao, Dabeeru C. ; Rotimi, Charles N. ; Cupples, L. Adrienne | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Nature Genetics | ||||
| Publisher: | Nature | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 51 | ||||
| Number of Issue or Book Chapter: | 4 | ||||
| Page Range: | pp. 636-648 | ||||
| Date: | 2019 | ||||
| Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
| Identification Number: |
| ||||
| Keywords: | ENVIRONMENT INTERACTION; GENOTYPE IMPUTATION; NICOTINE METABOLISM; RISK LOCI; METAANALYSIS; ARCHITECTURE; CHOLESTEROL; CIGARETTES; VARIANTS; SUSCEPTIBILITY; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 48830 |
Abstract
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci ...

Abstract
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Metadata last modified: 03 Sep 2021 10:03
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