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Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells

Bhat, Jaydeep ; Dubin, Samuel ; Dananberg, Alexandra ; Quabius, Elgar Susanne ; Fritsch, Juergen ; Dowds, C. Marie ; Saxena, Ankit ; Chitadze, Guranda ; Lettau, Marcus ; Kabelitz, Dieter


The functional plasticity and anti-tumor potential of human gamma delta T cells have been widely studied. However, the epigenetic regulation of gamma delta T-cell/tumor cell interactions has been poorly investigated. In the present study, we show that treatment with the histone deacetylase inhibitor Valproic acid (VPA) significantly enhanced the expression and/or release of the NKG2D ligands ...


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